Here's a random few I picked out that never made it to storylines, but still amuse me:
escalope - noun for a rapid but dignified getaway
fable - an unreliable item of furniture with a tendency to disappear completely for periods of time
fingerprints - thumbnail sized works of fine art
investigate - help people to find suitable items of clothing to wear
jitters - people who can only be found in alleyways, passages etc.
kindred - a scary clan
poppycock - a rare and colourful condition affecting the male organ
novice - a person capable only of virtue
pillar - a vendor of dubious medicines
qualm - a period of time (often years) in which nothing eventful happens
You get the picture, I'm sure.
There are, I freely admit, one or two precedents for this at least. One is certainly Douglas Adams' 'The Meaning of Liff' in which he lists place names and attributes often well-funny meanings to them. Another is to be found in the Radio 4 programme 'I'm Sorry I Haven't a Clue' and its 'Uxbridge English Dictionary' feature in which the esteemed panel find new meanings for words, almost invariably using the pun approach. All good stuff, but - so far as I know - no one has ever used these definitions/re-definitions as a basis for stories.
So I'll get on to that part of the process next time I hit the 'post' button. 'Til then, walk tall, walk straight and look the whole world in the eye (except on bent, wiggly, astigmatic days).